Apoptosis and Its Relevance to Autoimmunity (Current Directions in Autoimmunity, Vol. 9) - kelloggchurch.org

Elkon K ed: Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun. Basel, Karger, 2006, vol 9, pp 1–17 Death Receptor Signaling and Its Function in the Immune System Stefanie C. Fas, Benedikt Fritzsching, Elisabeth Suri-Payer, Peter H. Krammer Tumor Immunology Program, Division of. Mar 06, 2000 · An alternative model of how dysregulation of apoptosis may contribute to autoimmunity is that if rates of apoptosis are abnormally high in certain tissues, this may result in the presentation of.

Dec 01, 2000 · To try to understand autoimmunity, attention has often fallen on the process of cell death. After all, apoptosis is used during selection of immunocytes, cells in the target organs end up dying and mutations to cell death genes have been found in some autoimmune diseases. Apoptosis and autoimmunity are two phenomena, which share essential similarities in destroying cells. However, apoptosis is a normal process, while autoimmunity is not. Apoptosis could, at least in some conditions, cause autoimmunity. The failure to appropriately achieve programmed cell death and to clear apoptotic cell fragments is. Apoptosis is a normal part of development and is required during development, creation of the central nervous system, degeneration of the tadpole tail during metamorphosis, and the loss of certain appendages during the larval to pupal metamorphosis in holometabolous insects. Apoptosis is a major aspect of development and homeostasis. Apoptosis and Its Relevance to Autoimmunity Editors: Elkon, K.B. Seattle, WA. B Cell Biology in Autoimmunity: TOC: Vol. 5, 2002: Signal Transduction Pathways in Autoimmunity. Vol. 1, 1999: Genes and Genetics of Autoimmunity: TOC: Bibliographic Details. Current Directions in Autoimmunity Abbreviation: Curr Dir Autoimmun ISSN: 1422-2132.

Strasser, A., Whittingham, S., Vaux, D.L. et al. Enforced Bcl-2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Introduction The death of lymphocytes by apoptosis is an important mechanism for maintaining self-tolerance and homeostasis in the immune system. Failure of apoptotic cell death has long been postulated as a cause of loss of self-tolerance and the development of autoimmunity. Apoptosis results in the oxidation of membrane lipids on the dying cell. Newly identified oxidized lipids play a dual role: they contribute to the recognition and phagocytosis of dying cells, but. TY - JOUR. T1 - Autoantibody-induced apoptosis as a possible mechanism of autoimmune retinopathy. AU - Adamus, Grazyna. PY - 2003/3/1. Y1 - 2003/3/1. Jun 30, 2014 · Systemic lupus erythematosus SLE is a multisystem autoimmune disorder with a variety of proposed pathogeneses. Apoptosis is one of several important mechanisms involved in the pathogenesis of SLE. A previous study has demonstrated that lymphocyte apoptosis is increased and removal of apoptotic cells is impaired in SLE.

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