Cell Volume Regulation (Contributions to Nephrology, Vol. 123) - kelloggchurch.org

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Jul 07, 2015 · Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these ions. Gastrointestinal absorption is balanced by renal excretion. When body stores of these ions decline significantly, gastrointestinal absorption, bone resorption, and renal tubular reabsorption increase to. Failure to regulate cell volume with ensuing cell dehydration has long been recognized as a feature of red cells in sickle cell disease, Hb SC disease and Hb CC disease. 94,95 However, in contrast to DHS, in which cell dehydration is the only dominant feature, red cells in hemoglobinopathies are not only dehydrated but also exhibit significant. It is becoming apparent that I Cl.vol may play a key role in more general cell functions, including cell volume regulation, cell proliferation, and cell apoptosis. 11,12 Our data provide a new insight into our understanding of the role of I Cl.vol in some pathological processes, such as cerebrovascular remodeling, leading to stroke in hypertension. Research output: Contribution to journal › Review article Ferrè, S & Igarashi, P 2019, ' New insights into the role of HNF-1β in kidney pathophysiology ', Pediatric Nephrology, vol. 34, no. 8, pp. 1325-1335. Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of acid-base homeostasis. However, in recent years the understanding of the function of the intercalated cell has become greatly enhanced and has shaped a new model for how the distal segments of the kidney tubule integrate salt and water reabsorption, potassium homeostasis, and acid-base status.

Tsetse flies Diptera: Glossinidae constitute a small, ancient taxon of exclusively hematophagous insects that reproduce slowly and viviparously. Because tsetse flies are the only vectors of pathogenic African trypanosomes, they are a potent and constant threat to humans and livestock over much of sub-Saharan Africa. Despite their low fecundity, tsetse flies demonstrate great resilience. The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and. The Annual Review of Cell and Developmental Biology, in publication since 1985, covers the most significant developments in the field of cell and developmental biology, including structure, function, and organization of the cell, development and evolution of the cell as it relates to single and multicellular organisms, and models and tools of molecular biology. Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut–liver axis - Volume 78 Issue 3 - N. M. Delzenne, C. Knudsen, M. Beaumont, J. Rodriguez, A. M. Neyrinck, L. B. Bindels.

Various bacterial toxins, haemolysins and extracellular ATP activate the inflammasome via P2X7 channels, whereas, several crystals, such as hemozoin, silica and antibiotics, and anti-fungal drugs activate the inflammasome via both reactive oxygen production and cathepsin-B. Volume 132, 2020 Vol 131, 2019 Vol 130, 2018 Vol 129, 2017 Vol 128, 2016 Vol 127, 2015 Vol 126, 2014 Vol 125, 2013 Vol 124, 2012 Vol 123, 2011 Vol 122, 2010 Vol 121, 2009 Vol 120, 2008 Vol 119, 2006 Vol 118, 2005 Vol 117, 2005 Vol 116, 2004 Vol 115, 2004 Vol 114, 2003 Vol 113, 2003 Vol 112. Adrenal insufficiency due to recurrent renal cell.

Cell Volume Regulation (Contributions to Nephrology, Vol. 123)

Renal Control of Calcium, Phosphate, and Magnesium.

T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP-generating processes, whereas proliferating effector T cells require high metabolic flux through growth-promoting pathways. Further, functionally distinct T cell subsets require distinct energetic and. Mechanistically, stromal cell miRNAs suppressed in stromal cells with Dicer1 mutation are involved in migration, proliferation, and cell‐cell signaling. Additional ex vivo experiments using a human stromal cell line identified some miRNAs associated with stromal cells functions, such as miR‐214, miR‐199a‐5p, and miR‐199a‐3p. 31. Feb 01, 2014 · Introduction. The genomic landscape of clear cell renal cell carcinoma RCC was long thought to be dominated by the mutation of the von Hippel–Lindau tumor suppressor, E3 ubiquitin protein ligase VHL gene located on the short arm of chromosome 3 3p25.Loss of VHL function has upregulating effects on hypoxia-inducible factors, which play a key role in triggering neoangiogenic.

Sep 20, 2006 · Whereas an active NOX2-containing enzyme has been described in endothelial cells, the contribution of recently identified NOX homologues to endothelial ROS production and proliferation has been controversial. The authors, therefore, compared the role of NOX2 with NOX4 and NOX1 in endothelial EaHy926 and human microvascular endothelial cells. Dec 01, 2014 · Excess extracellular volume is a major clinical problem in patients with chronic kidney disease CKD. However, whether the extracellular volume status is associated with disease progression is unclear. We investigated the association between the extracellular volume status and renal outcomes. We performed a retrospective cohort study of 149 patients with CKD who underwent bioelectrical. Acute kidney injury AKI independently increases morbidity and mortality in children admitted to the hospital. Renal replacement therapy RRT is an essential therapy in the setting of AKI and fluid overload. The decision to initiate RRT is complex and often complicated by concerns related to patient hemodynamic and thermodynamic instability. A serine/threonine kinase Akt is a key mediator in various signaling pathways including regulation of renal tubular transport. In proximal tubules, Akt mediates insulin signaling via insulin receptor substrate 2 IRS2 and stimulates sodium-bicarbonate cotransporter NBCe1, resulting in increased sodium reabsorption. In insulin resistance, the IRS2 in kidney cortex is exceptionally preserved. May 04, 2020 · Mesoamerican nephropathy MeN is a pattern of chronic kidney disease CKD prevalent among Central American men who work in agriculture, and its underlying cause has not been elucidated. Currently, experts hypothesize that MeN is related to repeated episodes of occupational heat stress leading to water loss and hence it is also called dehydration-associated CKD. We report a case of a.

Sommerfeld, HJ, Partin, AW & Pannek, J 2002, ' Incidence of neuroendocrine cells in the seminal vesicles and the prostate - An immunohistochemical study ', International urology and nephrology, vol. 34, no. 3, pp. 357-360. The serum- and glucocorticoid-regulated kinase SGK was originally cloned from rat mammary tumor cells as a glucocorticoid responsive gene. 1 The human isoform was subsequently cloned as a cell volume–sensitive gene upregulated by both hypertonic and isotonic cell shrinkage. 2,3 Because of the discovery of the 2 isoforms SGK2 and SGK3, 4 the originally cloned kinase is labeled SGK1.

Nephrology Dialysis Transplantation, Volume 29, Issue 7, July 2014, Pages 1312–1319, https. has also pointed to a possible role for SGK-2 and its stimulatory impact on NHE3 function in rat kidney proximal tubule cells. The regulation of NHE3 by. Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by. Apr 26, 2019 · In mammals, multiciliated cells MCC are terminally differentiated epithelia that line the respiratory tract, brain ventricles and segments of the female and male reproductive organs Brooks and Wallingford, 2014; Spassky and Meunier, 2017.Each MCC contains hundreds of motile cilia, microtubule-based organelles that generate the motive force to move fluid over the surface of the cell. Fetuin A; IGF-1, MIP-1α, and vascular cell adhesion molecule-1 were highest in PH1 > IHC p < 0.001 to p = 0.005. Conclusion: PH1 Ur-PROs reflected overt inflammation, chemotaxis, oxidative stress, growth factors including EGF, and pro-angiogenic and calcification regulation/inhibition compared to. The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma Cancer Cell, Vol. 1, No. 3 Clinical and molecular analysis of disseminated hemangioblastomatosis of the central nervous system in patients without von Hippel—Lindau disease. Journal of the American Society of Nephrology: Volume: 3: Issue number: 5: State: Published - Nov 1 1992: Fingerprint; Clusterin. Kidney. Journal of the American Society of Nephrology, Vol. 3, No. 5, 01.11.1992, p. 1172-1179. cell aggregation, and regulation of the cytolytic activity of the membrane attack complex of complement.

Mar 08, 2011 · 27 August 2015 Cell Death & Disease, Vol. 6, No. 8 Role of high-mobility group box-1 protein in disruption of vascular barriers and regulation of leukocyte–endothelial interactions 19 November 2014 Journal of Receptors and Signal Transduction, Vol. 35, No. 4. HEK293 cells transiently transfected with the mutant TRPV4 N651Q exhibited increased calcium entry in response to hypotonic stress relative to wild-type TRPV4 transfectants. This increase in hypotonicity responsiveness was associated with an increase in plasma membrane targeting of TRPV4 N651Q relative to wild-type TRPV4 in both HEK293 and COS. To cite the regulations in this volume use title, part and section number. Thus, 45 CFR 1.1 refers to title 45, part 1, section 1. Explanation. The Code of Federal Regulations is a codification of the general and permanent rules published in the Federal Register by the Executive departments and agencies of the Federal Government. Volume 123, Issue 2. February 2020. Pages 451-785. Volume 123, Issue 1. January 2020. Pages 1-450. Collections;. Top-Down Regulation of Plasticity in the Birdsong System: “Premotor” Activity in the Nucleus HVC Predicts Song Variability Better Than It Predicts Song Features. Cell, Vol. 100. Altered Taste Responses in Adult NST After.

Because kinesin-12 family members participate in orienting cell division, downregulation of Kif12 may underlie the abnormal planar cell polarity observed in cystic kidney diseases. AB - Hepatocyte nuclear factor-1β HNF-1β is a transcription factor that regulates gene expression in the kidney, liver, pancreas, and other epithelial organs. The results indicate that 11β-hydroxysteroid dehydrogenase is expressed by DCT cells, as well as connecting tubule cells and principal cells of the collecting duct; expression levels are low near the junction with the thick ascending limb and rise near the transition to the connecting tubule. In: Journal of the American Society of Nephrology, Vol. 22, No. 3, 01.03.2011, p. 460-471. Research output: Contribution to journal › Article Cheng, CJ & Huang, CL 2011, ' Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1 ', Journal of the American Society of Nephrology, vol. 22, no. 3. SPECIFIC AIMS. Megalin is an endocytic receptor in proximal tubular cells PTC that mediates cellular uptake of 25-OH vitamin D 3 complexed with the vitamin D binding protein DBP. The receptor is responsible for the renal uptake and activation of 25-OH vitamin D 3 to 1,25-OH 2 vitamin D 3, a central step in vitamin D metabolism.Unfortunately, the perinatal lethality of the conventional. In: European Journal of Pharmacology, Vol. 65, No. 1, 01.01.1980, p. 123-124. Research output: Contribution to journal › Article Innis, RB & Snyder, SH 1980, ' Cholecystokinin receptor binding in brain and pancreas: Regulation of pancreatic bindign by cyclic and acyclic guanine nucleotides '.

Those cells then migrate and infiltrate the kidney. On the other hand, PD-1 contributes to tolerance primarily at the level of target organs. In the renal tissue, there is upregulation of PD-L1 by renal cells, which will bind and signal through PD-1 expressed by T cells, trying to prevent those cells from proliferating and damaging the tissue. Volume 123 Issue 6. December 2017. Pages 1423-1738. Volume 123 Issue 5. November 2017. Pages 1021-1422. 1 December 2017 Journal of Applied Physiology, Vol. 123, No. 6. Thermal regulation and comfort during a mild-cold exposure in young Japanese women complaining of unusual coldness. These results indicate a new role for α-catenin in local regulation of actin assembly and organization at sites of cadherin-mediated cell-cell adhesion. AB - Epithelial cell-cell junctions, organized by adhesion proteins and the underlying actin cytoskeleton, are considered to be stable structures maintaining the structural integrity of tissues. Space flight exerts substantial effects on fluid volume control in humans. Cardiac distension occurs during the first 1–2 days of space flight relative to supine and especially upright 1 g conditions. Plasma volume contraction occurs quickly in microgravity, probably as a result of transcapillary fluid filtration into upper-body interstitial spaces.

To cite the regulations in this volume use title, part and section number. Thus, 40 CFR 82,1 refers to title 40, part 82, section 1. Explanation. The Code of Federal Regulations is a codification of the general and permanent rules published in the Federal Register by the Executive departments and agencies of the Federal Government.

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