The inverse relationship between cell cross-sectional area and cell length Fig. 3 and Table 1 indicates that the cell volume was indeed the same within the lengths studied. The 35.6% ± 10.6 and the 76% ± 9.8 increase in thick filament density found at 50 and 100% length increase, therefore, closely fits the model prediction Fig. 4. In this Special Issue entitled "Molecular Regulation of the Endomembrane System", we are seeking novel research or review articles highlighting the variety of machinery and regulatory mechanisms used in membrane traffic, with specific regard to how membrane flux is controlled and how it determines the identity and function of organelles. May 01, 2012 · 2. Embryonic stem cells. Embryonic stem cells ESCs are derived from the inner cell mass of blastocysts, and they have the pluripotent differentiation ability to give rise to cells of all three germ layers, which makes them an invaluable source for cell therapy in clinical application.There are plenty of studies focusing on the regulation of pluripotency and differentiation of ESCs, and some.
Dear Colleagues, Ion transport across cell membranes, mediated by ion transporters and channels, play important roles in the control of bodily and cellular functions, such as the actions of hormones and enzymes, cell growth, including aberrant cancer cell proliferation, neurite elongation, and transepithelial ion and water transport, which is crucial for blood pressure control, electrolyte. Ionic signalling is the most ancient form of regulation of cellular functions in response to environmental challenges. The first section of this special issue provides updates on the regulation of NKA and its function as a. M.P. BlausteinEvolution of our understanding of cell volume regulation by the pump-leak mechanism. J. Gen. Physiol. Delta-lactoferrin, an intracellular lactoferrin isoform that acts as a transcription factor 1 This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal's usual peer review process. Biochemistry and Cell Biology 2012, 90 3, 307-319. DOI: 10.1139/o11-070. Endothelial cell growth and survival are dependent on several factors, including the presence of specific growth factors and cellular interactions with the extracellular matrix. In vitro, growth factor deprivation leads to apoptosis, whereas cell detachment leads to a special form of programmed cell.
Jan 01, 2016 · This article is part of a Special Issue entitled Crystallin Biochemistry in Health and Disease. Structural and functional significance of crystallin protein–protein interaction in lens. All forms of crystallin take part in cell physiology as a complex interacting with each other thereby accomplishing their structural and functional role. Cellular metabolism depends on the appropriate concentration of intracellular inorganic phosphate Pi. Pi starvation-responsive genes appear to be involved in multiple metabolic pathways, implying a complex Pi regulation system in microorganisms and plants. A group of enzymes is required for absorption and maintenance of adequate phosphate levels, which is released from phosphate esters and. Special attention has been given to the signaling pathways involved in the transporter's regulation found in several tissues and cell types, and more specifically, in vascular smooth muscle cells. Single-cell pH-sensing and accurate detection and label-free fast identification of cancer-cells are two long-standing pursuits in cell and life science, as intracellular pH plays a crucial role.
Apr 01, 2018 · These studies are reviewed in an effort to better appreciate the relationship between Maf1 function and cell physiology. This article is part of a Special Issue entitled: SI: Regulation of tRNA synthesis and modification in physiological conditions and disease edited by Dr. Boguta Magdalena. Reactive oxygen species ROS and autophagy are two highly complex and interrelated components of cell physiopathology, but our understanding of their integration and their contribution to cell homeostasis and disease is still limited. Sestrins SESNs belong to a family of highly conserved stress-inducible proteins that orchestrate antioxidant and autophagy-regulating functions protecting. Jun 01, 1993 · 1 January 2000 American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 278, No. 1 The mechanics of exaggerated airway narrowing in asthma: the role of smooth muscle Respiration Physiology, Vol. 118, No. 1. Recently, a growing body of evidence has shown the role of reactive species as secondary messengers in cell proliferation and differentiation, as opposed to the harmful metabolism byproducts that they were previously solely recognized as. Thus, the balance of intracellular reduction-oxidation redox homeostasis plays a vital role in the regulation of stem cell self-renewal and differentiation. This brief prospective overview focuses mainly on issues that must be resolved if we are to understand the role of cell walls in plant physiology. Many outstanding reviews cover recent progress, including a series of excellent updates in a recent special issue of Plant Physiology focused on this topic see McCann and Rose, 2010.
cell volume regulation is fundamental in their physiology. The aim of the present work was to study the physiological response to hypotonic stress in a salt-transporting. American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 275, No. 2 Dexamethasone Is a Novel Potent Inducer of Connective Tissue Growth Factor Expression 17 July 1998 Journal of Biological Chemistry, Vol. 273, No. 29. Sep 25, 2019 · One of useful approaches to studying protein functions in living cells is the use of fluorescent substrate probes. Fluorescent substrate probes are molecules that are designed to report targeted enzymatic reactions with fluorescence signal change, and with high sensitivity and real-time application, the tools are especially useful in reporting cellular functionalities through live cell imaging. Okada SF, O'Neal WK, Huang P, Nicholas RA, Ostrowski LE, Craigen WJ, Lazarowski ER, Boucher RC. Voltage-dependent anion channel-1 VDAC-1 contributes to ATP release and cell volume regulation in murine cells. J. Gen. Physiol. 2004; 124:513–526. [PMC free article]. Lomax et al.  suggested their involvement in cell Cellular Physiology and Biochemistry volume homeostasis in human colonic crypts. Cell Volume Regulation and Apoptotic Volume Decrease in.
Aug 01, 2015 · General significance. We provide an initial evaluation of ROS signaling cascades involved in cell differentiation in plants and identify potential avenues for future studies. This article is part of a Special Issue entitled Redox regulation of differentiation and de-differentiation. At present, when the technological progress brings progressive increase in environmental pollutions by different chemical and physical ionizing and non-ionizing radiations factors, the detection of the safety of environmental medium from the point of public health is one of the fundamental problems of modern Life Sciences. This problem has especially disquieting character after the Chernobyl. Jun 27, 2007 · The largest cells quantified were ∼10-fold larger in volume than the smallest cells; examples are shown in Figure 4C. Cross-sectional cell and nuclear area was measured for cells of all three types, and once again, it was apparent that nuclear area increased with cell area, even though all cells were in G1-phase Figure 4D, r = 0.77, n = 85. An immortalized myocyte cell line, HL-1, expresses a functional delta-opioid receptor. J Mol Cell Cardiol 32: 2187–2193, 2000. Crossref PubMed ISI Google Scholar; 47 Nguyen SV and Claycomb WC. Hypoxia regulates the expression of the adrenomedullin and HIF-1 genes in cultured HL-1 cardiomyocytes. Biochem Biophys Res Commun 265: 382–386, 1999.
PNAS commits to immediately and freely sharing research data and findings relevant to the novel coronavirus COVID-19 outbreak. See the free collection of PNAS coronavirus papers and learn more about our response to COVID-19. Feb 01, 2003 · Cells were seeded in 100-ml, 96-well plates 3,200 cells/well, 10,000 cells/cm 2. After 24 h, experimental agents were applied 100 ml and the cultures were incubated for 1, 3, or 5 days at 37°C. After 24 h, experimental agents were applied 100 ml and. In endothelial cells, mitochondria comprise less than 5% of total cellular volume Fig. 1 compared to around 28% in hepatocytes. That and the point that endothelial cells do not necessarily depend on OXPHOS in order to produce ATP [ 118 ] have led to the fact that the role of mitochondria in endothelial physiology and pathology has been.
Ca 2 Uptake by Mitochondria: To Take or Not to Take a Historical Note. The affinity of mitochondria for Ca 2 uptake is low: in the 10 −6 –10 −4 M range 11, 16, 57, 71.A suggestion that mitochondrial Ca 2 uptake might dominate Ca 2 homeostasis was put forward for the cycle of contraction and relaxation of “red” muscle, which is rich in mitochondria 8, 42, 57. acute inflammation is host protective and mounts in response to tissue injury from within or invading microbes.It is now recognized that failure to engage resolution mechanisms could underlie persistent low-grade inflammation that is associated with many chronic diseases including rheumatoid arthritis, periodontal disease, asthma, diabetes, and inflammatory bowel disease IBD, as well as.
Inflammasome assembly is initiated by cytosolic sensors in response to microbial infections. Many of these sensors, including NLRP1 NLR family, pyrin domain containing 1, are described to form an inflammasome, but until recently, the mechanism of inflammasome activation and its physiological functions in host defense have remained unclear. Anion exchanger 3 AE3, expressed in the brain, heart, and retina, extrudes intracellular HCO3− in exchange for extracellular Cl−. The SLC4A3 gene encodes two variants of AE3, brain or full-length. Ion transport across the cell membrane plays a crucial role in fundamental tumour cell functions [1–3], such as cell volume regulation [4,5], migration, cell cycle progression [5,6], cell proliferation [5,6] as well as cell death [4,5]. All those functions are critically important for tumour cell survival and metastasis.
Epithelial cell tight junctions TJs consist of a narrow belt-like structure in the apical region of the lateral plasma membrane that circumferentially binds each cell to its neighbor. TJs are found in tissues that are involved in polarized secretions, absorption functions, and maintaining barriers between blood and interstitial fluids. The morphology, permeability, and ion selectivity of TJ. Mar 15, 2018 · The functional significance of mitochondrial Ca 2 accumulation started to be elucidated when it was demonstrated that mitochondrial Ca 2 regulates three key enzymes of mitochondrial metabolism: ketoglutarate dehydrogenase, isocitrate dehydrogenase, and pyruvate dehydrogenase phosphatase 1 PDP1. The net effect on tricarboxylic acid TCA cycle activation is a boost in the.
Cremer, T. and C. Cremer. 2001. Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nature Reviews Genetics 2: 292-301. Science magazine, special issue on "Epigenetics", 10 August 2001, Vol. 293 5532. Duboule, D. and G. Morata. 1994. Colinearity and functional hierarchy among genes of the homeotic complexes. Drought and heat are among the major abiotic stresses that affect soybean crops worldwide. During the current investigation, the effect of drought, heat, and drought plus heat stresses was compared in the leaves of two soybean varieties, Surge and Davison, combining 2D-DIGE proteomic data with physiology and biochemical analyses. We demonstrated how 25 differentially expressed. American Journal of Physiology-Cell Physiology, Vol. 312, No. 4. The International Journal of Biochemistry & Cell Biology, Vol. 45, No. 7. in the aorta of hereditary hypertriglyceridemic ratsThis article is one of a selection of papers published in a special issue on Advances in. Small ubiquitin‐related modifier SUMO is a member of a ubiquitin‐like protein family that regulates cellular function of a variety of target proteins. SUMO and ubiquitin are synthesized as precurso.
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