Current Research in Head and Neck Cancer: Molecular Pathways, Novel Therapeutic Targets, and Prognostic Factors (Advances in Oto-Rhino-Laryngology, Vol. 62) -

Current Research in Head and Neck CancerMolecular.

May 31, 2016 · Head and neck squamous cell carcinoma HNSCC, which represents more than 95 % of head and neck cancers, is the sixth most common tumor entity worldwide. Therapy options are mostly restricted to surgery and radio- and/or chemotherapy resulting in a 5-year survival rate of around only 50 % depending on the stage at time of diagnosis [ 1, 2 ]. Jan 17, 2019 · Carrero, I., Liu, H., Sikora, A.G. et al. Histoepigenetic analysis of HPV- and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets. Dec 01, 2004 · Novel therapeutic targets in squamous cell carcinoma of the head and neck. F.N. SalamoneMolecular genetics of head and neck cancer. Cancer Control, 9 2002, pp. 369-378. In vitro growth suppression by adenoviral transduction of p21 and p16 in squamous cell carcinoma of the head and neck: A research model for combination gene therapy. Advances in Oto-Rhino-Laryngology Henning Bier - Current Research in Head and Neck Cancer_ Molecular Pathways, Novel Therapeutic Targets, And Prognostic Factors-S. Karger AG Switzerland 2004 Uploaded by. Corin Boice Tello. bahan THT dapus.docx. Uploaded by.

1. Introduction. Squamous cell carcinoma of the head and neck HNSCC is the sixth most common cancer with 500.000 diagnosis per year worldwide [].Patients with locally advanced disease have a chance of cure with multimodality treatments that involves surgery, radiotherapy, chemotherapy, and, in the last years, molecular targeted therapies []. Despite advances in local and systemic therapy, head and neck cancer remains a clinically challenging disease. For the past decade, clinical research in head and neck cancer has focused on improving on the benefits of chemotherapy and radiation by targeting the cellular pathways. MET and RON Receptor Tyrosine Kinases: Novel Therapeutic Targets in Squamous Cell Carcinoma of the Head and Neck Article PDF Available in Current Enzyme Inhibition 31:1-12 · February 2007. Head and neck squamous cell carcinoma HNSCC is the 5th most common cancer worldwide, and accounts for approximately 2.8% of all malignancies in the United States. 1 In 2004, an estimated 38,530 Americans developed HNSCC and 11,060 died of this disease. 2 Considerable advances in the surgical and medical treatments for HNSCC over the past two decades unfortunately have not improved overall. RESULTS. TGF‐α protein staining occurred in the suprabasal layers and spared the basal layer of normal controls. Conversely, in histologically normal mucosa from SCCHN patients.

Jul 19, 2016 · Head and Neck cancer is a common tumor entity worldwide with 5‐year survival rates of only 50% 5 and therefore presents a clinical challenge. Increased DDR2 expression has been shown in several tumor types such as breast and lung cancer. 22, 23 Moreover, we and others 19 could show high DDR2 protein expression in HNSCC. 1. Introduction. Head and neck cancer is a prevalent condition in the United States and the eighth leading site of new cancer cases among men. It is estimated that 35,310 new cancers of the oral cavity and pharynx will have been diagnosed in 2008 in the United States, and that 7,590 Americans will have died due to such cancers [].More than 80% of head and neck cancers excluding cancers of the. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010;11:21-8 148. Lu JM, Wang X, Marin-Muller C. et al. Current advances in research and clinical applications of PLGA-based nanotechnology. The treatment of head and neck cancer has been at the forefront of novel therapeutic paradigms. The introduction of drugs that interact with selective biologic pathways in the cancer cell has generated considerable attention recently. A wide variety of new compounds that attempt to target growth-signaling pathways have been introduced into the clinic. Nulton TJ, et al. Analysis of The Cancer Genome Atlas sequencing data reveals novel properties of the human papillomavirus 16 genome in head and neck squamous cell carcinoma. Oncotarget. 2017;811:17684–99.

Jun 01, 2010 · Current potential and limitations of molecular diagnostic methods in head and neck cancer Current potential and limitations of molecular diagnostic methods in head and neck cancer Mahfouz, Magdy; Rodrigo, Juan; Takes, Robert; Elsheikh, Mohamed; Rinaldo, Alessandra; Brakenhoff, Ruud; Ferlito, Alfio 2010-06-01 00:00:00 Eur Arch Otorhinolaryngol 2010 267:851–860 DOI. The new era of cancer immunotherapy: manipulating T-cell activity to overcome malignancy. In Advances in Cancer Research; Elsevier: Amsterdam, The Netherlands, 2015; Volume 128, pp. 1–68. ISBN 0065-230X. [Google Scholar] Lubek, J.E. Head and Neck Cancer Research and Support Foundations. Oral Maxillofac. Surg. Clin. 2018, 30, 459–469. Prognostic significance of [18 F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study 98.02.

Last, p53 has been used as a prognostic marker for current head and neck cancer therapy Dijkema et al., 2000; Obata et al., 2000; Temam et al., 2000; Warnakulasuriya et al., 2000. These studies mostly correlate the mutation of p53 with an unfavorable response to chemotherapy and radiation. Efforts are focused on omics profiling, prediction of metastasis and signaling pathways and validation for head and neck cancer through the application of various omics technologies—genomics, transcriptomics, proteomics, metabolomics, peptidomics, glycomics, lipidomics—on tissue samples, cell lines and body fluids. Jan 01, 2017 · Free Online Library: CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches.Report by "Contrast Media & Molecular Imaging"; Health, general Antibodies Health aspects Diagnostic imaging Methods Head and neck cancer Diagnosis Medical imaging equipment Squamous cell carcinoma Viral antibodies. Head and neck squamous cell carcinomas are among the most common neoplasms worldwide and characterized by local tumor aggressiveness, high rate of early recurrences, development of metastasis, and second primary cancers. Despite modern therapeutic strategies and sophisticated surgical management, overall survival-rates remained largely unchanged over the last decades. Thus, the need for novel. International Journal of Otolaryngology and Head & Neck Surgery Vol.04 No.032015, Article ID:55783,9 pages 10.4236/ijohns.2015.43031. Prognostic and Predictive Protein Biomarkers in Laryngeal Squamous Cell Carcinoma―A Systematic Review.

Activation of the phosphatidylinositol-3-kinase PI3K pathway is one of the most frequently observed molecular alterations in many human malignancies, including head and neck squamous cell carcinoma HNSCC. A growing body of evidence demonstrates the prime importance of the PI3K pathway at each stage of tumorigenesis, that is, tumor initiation, progression, recurrence, and metastasis. Analysis of cancer pathways revealed that the PI3K pathway was most commonly affected. Alterations in the cell cycle pathway were associated with impaired disease-free survival HR 2.6, P= 0.038. Three subgroups based on AR andERBB2 status were identified, which featured distinct molecular. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res. 2012;181: 290 – 300. [Google Scholar] 80. Nemunaitis J, Nemunaitis J. Head and neck cancer: response to p53-based therapeutics. Head Neck. 2011;331: 131 – 134. [Google Scholar] 81. Elucidation of this novel mechanism of nicotine-dependent nuclear transactivation of STAT-3 identifies oral α7 nAChR as a promising molecular target to prevent, reverse, or retard tobacco-related periodontal disease and progression of head and neck cancer by receptor inhibitors.—Arredondo, J., Chernyavsky, A. I., Jolkovsky, D. L., Pinkerton.

Aug 19, 2019 · Systemic Symptoms and Sickness Behavior. Disease processes including cancer, infection, or clinically significant trauma evoke a stereotypic neurohumoral response intended to aid the body in its recovery.Activation of these same biological processes results in general symptoms as well as adaptive behaviors 2, 3.In the short run, this may be physiologically beneficial; however, in the. Worldwide, Head and Neck Squamous Cell Carcinoma HNSCC is the sixth most malignant tumor. Yearly, 650.000 new cases are estimated; nearly 50% will later die due to the disease.In the USA, 45.660 new cases were diagnosed in 2007, corresponding 3.2% of all new cancer cases.The incidence for Germany and other western European states as well as for the USA is estimated to be 15/100.000. This article reviews progress in chemopreventive drug development, especially data and concepts that are new since the 2002 AACR report on treatment and prevention of intraepithelial neoplasia. Molecular biomarker expressions involved in mechanisms of carcinogenesis and genetic progression models of intraepithelial neoplasia are discussed and analyzed for how they can inform mechanism-based.

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