Gene Therapy for Renal Diseases and Transplantation (Contributions to Nephrology, Vol. 159) - kelloggchurch.org

Initially conceived as a strategy to remedy inherited genetic disorders, gene therapy has been successfully applied in the last decade to ameliorate the renal function compromised by progressive renal diseases and to prevent kidney allograft rejection in experimental animals. Dec 01, 2008 · Contributions to nephrology; v.159 RC903 Although it has proven itself useful in the treatment of genetic kidney disorders, it is only fairly recently that gene therapy has begun to fulfill its promise in treating acute and chronic graft rejection, renal cancer, and HIV-related nephropathy. Gene Therapy for Renal Diseases and Transplantation G. Remuzzi, A. Benigni Initially conceived as a strategy to remedy inherited genetic disorders, gene therapy has been successfully applied in the last decade to ameliorate the renal function compromised by progressive renal diseases and to prevent kidney allograft rejection in experimental animals. Summary: Initially conceived as a strategy to remedy inherited genetic disorders, gene therapy has been successfully applied in the last decade to ameliorate the renal function compromised by progressive renal diseases and to prevent kidney allograft rejection in experimental animals. Abstract During the last 20 years there have been major improvements in renal replacement therapy, including dialysis and kidney transplantation; however, the treatment options for renal diseases are still limited. Gene therapy is a potential modality for many renal diseases for which we are as yet unable to offer specific treatment.

Gene transfer in experimental animals have been tested in all of these conditions, as well as in animal kidney transplantation models, with various degrees of success. However, there are many obstacles to be overcome before gene therapy can be tested clinically for renal disorders. Contributions to Nephrology. Editors: Ronco, Claudio Vicenza. Therapy for chronic kidney disease Online access TOC. Vol. 197, 2019 available Active subscription Remote Patient Management in Peritoneal Dialysis Editors: Ronco, Claudio Vicenza. Vol. 159, 2008: Gene Therapy for Renal Diseases and Transplantation: TOC: Vol. 158. If there is a near-term role for gene therapy in renal disease, it may be of the latter form, according to Leo Deelman, PhD, assistant professor of medicine at the University of Groningen, the Netherlands. One strategy is to use gene therapy to provide local immune suppression for renal transplantation.

Jun 22, 2019 · In GSD I, renal replacement therapy with dialysis or transplantation is considered in the case of advanced chronic kidney disease failing to respond to metabolic control or other interventions. In GSD III, patients have been reported with liver, kidney and heart transplant. accumulated. Transplant kidney is an ideal target for gene therapy, by which ischemia reperfusion, acute rejection and chronic allograft nephropathy can be treated. The importation of the novel technology, for example hybrid stem cell-gene therapy could promote the gene therapy of renal diseases toward. lated. Transplant kidney is an ideal target for gene therapy, by which ischemia reperfusion, acute rejection and chronic allo-graft nephropathy can be treated. The importation of the novel technology, for example hybrid stem cell-gene therapy could promote the.

Gene Therapy for Renal Diseases and Transplantation (Contributions to Nephrology, Vol. 159)

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