Gene Therapy of Cochlear Deafness: Present Concepts and Future Aspects (Advances in Oto-Rhino-Laryngology, Vol. 66) -

May 26, 2009 · Gene Therapy of Cochlear Deafness: Present Concepts and Future Aspects Advances in Oto-Rhino-Laryngology, Vol. 66: 9783805590358:. Advances in Oto-Rhino-Laryngology Abbreviation: Adv Otorhinolaryngol ISSN: 0065-3071 Print e-ISSN: 1662-2847 Online DOI: 10.1159/issn.0065-3071. Gene therapy of cochlear deafness: present concepts and future aspects. [Allen F Ryan;] -- "This volume reviews current concepts and recent research findings of the application of gene therapy. Gene therapy of cochlear deafness: present concepts and future aspects. [Allen F Ryan;] -- Gene therapy holds great potential for the treatment not only of genetic disorders, but also of many acquired diseases. This is as true for the inner ear as for any other organ.

Jul 06, 2020 · Genomic advances for gene discovery in hereditary hearing loss. J Basic Clin Physiol Pharmacol 23: 93–97,. Canalostomy as a surgical approach for cochlear gene therapy in the rat. Anat Rec Hoboken 295: 1830–1836,. a new auditory prosthesis for neural deafness-concept and device description. Otol Neurotol 27: 838–843. Aug 01, 2019 · While early studies on gene therapy to the cochlea were often hampered by low transfection efficiency, largely a result of the method of delivery to the cochlea or the cell specificity of the viral serotype, recent developments in mode of delivery and viral vector technology in cochlear gene therapy research are eliminating this problem Lustig. Permanent hearing loss affects more than 5% of the world’s population, yet there are no nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the cochlea and vestibular system of the inner ear is complicated by their inaccessible location. Drug delivery to the inner ear via the vasculature is an attractive noninvasive strategy, yet the blood-labyrinth barrier.

Abstract. The prognosis of childhood hearing impairment depends upon the type of hearing disorder diagnosed, its severity and time of onset, the time points at which the hearing impairment was detected and treatment begun, the nature and quality of the treatment and of professional and family support and the presence of associated disorders. These findings reveal the potential utility of gene therapy with Sendai virus and HA for treatment of sensorineural hearing loss.Gene Therapy accepted article preview online, 11 September 2015.Background Sensorineural hearing loss is the most common sensory deficit in the world, with nearly 300 million affected individuals. The problem is multifactorial and can arise from damage or death of the primary sensory cells or the inner-ear neurons that relay auditory information to the brain. The inner-ear sensory cells and neurons can be damaged by environmental insult such as.

Gene therapy by nanoparticles will hopefully lead to the preservation of residual hearing in patients being affected by genetic hearing loss. Overall the cochlear implant is a very powerful tool to rehabilitate patients with sensory deafness.

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