select article S.H.H. Chan, J.Y.H. Chan Series Eds., Translational Research in Biomedicine. ISSN 1662-405X. Principles of Transformation and Pathogenesis. In vitro cell line and in vivo murine models have historically dominated pre-clinical cancer research. These models can be expensive and time consuming and lead to only a small percentage of anti-cancer drugs gaining a license for human use. Large animal models that reflect human disease have high translational value; these can be used to overcome current pre-clinical research limitations. translational research . NOD/Scid mice have been used. Journal of Immunology, vol. 169, no. 1, pp. 204–209, 2002. . it has become the most reliable in vivo human cancer model. The.
The development of humanized mice over the past few decades has enabled the examination of human haematopoiesis, immunity to infectious diseases, cancer and autoantibodies in mice. But are these. Clinical and translational research on ALDH2 deficiency associated diseases Edited by Dr Tse-Hua Tan. Thematic series Immunotherapy against cancer and immune disorders Edited by Dr John T Kung. 2015. Thematic series Application of zebrafish in biomedical research Edited by Prof Chiaho Shih. 2014. Thematic series Enterovirus 71 Edited by Prof. Introduction. Translational research is precisely defined by the National Institutes of Health NIH as “the process of applying ideas, insights and discoveries generated through basic scientific inquiry to the treatment or prevention of human disease” .As the field of translational research has become increasingly popular in recent years, it has undergone numerous reiterations, such.
His research interests have focused on the molecular biology and pathogenesis of retroviruses, including murine leukemia virus, jaagsiekte sheep retrovirus, SIV, HIV, and HTLV. He has served on and chaired the NIH Virology Study Section, and was an editor of the Journal of Virology. Aug 09, 2018 · human cancer cells and tissues under synchro tron radiation with the passage of time, Figures 1 and 2. Furthermore, it should be not ed that synchrotron and s ynchrocyclotron radiations. Department of Stem Cell and Regenerative Biology, Konkuk University, Seoul, South Korea Interests: reprogramming somatic cells to stem cells or cancer stem cells; reprogramming cancer cells or malignant cancer cells to normal or benign tumor cells; signaling pathways regulating stem cell self-renewal or oncogenesis metastasis, epithelial–mesenchymal transition EMT, or mesenchymal. Jul 15, 2020 · Translational Science. Inactivation of the Prolyl Isomerase Pin1 Sensitizes BRCA1-Proficient Breast Cancer to PARP Inhibition. Man-Li Luo, Fang Zheng, Wenying Chen,. Cancer Research Online ISSN: 1538-7445 Cancer Research Print ISSN: 0008-5472 Journal of Cancer Research ISSN: 0099-7013. Virologica Sinica publishes peer-reviewed original research articles and reviews concerning the latest developments in all branches of virology, including the research on the viruses of animals, plants and microbes. The journal welcomes studies on viruses as well as on viral infections and diseases. The journal will feature articles on new virus discovery, molecular characterization of viruses.
The importance of data science techniques in almost all fields of biomedicine is increasing at an enormous pace. This holds particularly true for the field of biomedical image analysis, which plays a crucial role in many areas including tumor detection, classification, staging and progression modeling as well as automated analysis of cancer cell images acquired using microscopy. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. In a recent editorial launching the new journal Science Translational Medicine, Dr. Elias Zerhouni, former director of the National Institutes of Health, remarked that despite decades of advances in our understanding of human biology and the emergence of powerful new technologies, such as genomics, the transformation of scientific discoveries into effective health interventions continues to.
Organoid cultures have emerged as powerful model systems accelerating discoveries in cellular and cancer biology. These three-dimensional cultures are amenable to diverse techniques, including high-throughput genome and transcriptome sequencing, as well as genetic and biochemical perturbation, making these models well suited to answer a variety of questions. Recently, organoids have been. The mission of our division is to improve the quality of interventional healthcare computationally. Our vision is to support physicians throughout the entire process of disease diagnosis, therapy and follow-up in a data-driven manner "the right information to the right person at the right time". Infection-associated cancers account for ∼20% of all malignancies. Understanding the molecular mechanisms underlying infection-associated malignancies may help in developing diagnostic biomarkers and preventative vaccines against malignancy. During infection, invading microbes interact with host mucins lining the glandular epithelial cells and trigger inflammation. MUC1 is a transmembrane.
Jul 08, 2020 · Translational Research in Liver Cancer HCC Summit, in Geneva, Switzerland, Feb. 15, 2014. 23. “Molecular classification and prognostic prediction of hepatocellular carcinoma” in annual meeting of American Association for Cancer Research, in San Francisco, Apr. 8, 2014. 24. 1. Introduction. Translational medicine is an interdisciplinary branch of biomedicine, which aims to translate results from preclinical in vitro and in vivo research to the clinical setting, the so-called "from bench to bedside" path .Its main objective is to improve prevention, diagnosis, and treatment strategies for human diseases by filling the gap between the preclinical and the. 5.2. Cell and tissue sourcing A critical issue to consider when selecting a cell or tissue based test system is the source of the cells or tissues, as its history/handling may influence its characteristics and, consequently, the results of the in vitro methods conducted with this test system Lorge et al., 2016.Sourcing of cells and tissues from a certified provider, e.g., established cell.
Oct 17, 2016 · Hodgkin lymphoma HL has been classified into classical HL cHL, 1, 2 which accounts for 95% of all HL cases, and the nodular lymphocyte predominant HL NLPHL, which is a separate entity. 3-5 cHL is a neoplastic disease with heterogeneous epidemiological, clinical, pathological, and virological features. It accounts for 10% of all lymphomas and is the most common cancer in patients under 20. Jul 16, 2019 · The interested readers are directed to read further text dedicated to the design principles of microrobots [5–13]. To avoid confusion and concentrate primarily on the translational prospects, the present review considers all sub-millimeter scale untethered robot designs cited herein a microrobot. Whether and how human tumours are genetically unstable has been debated for decades. There is now evidence that most cancers may indeed be genetically unstable, but that the instability exists at. Translational Research, Vol. 209. F1000Research, Vol. 8. Arquivos de Neuro-Psiquiatria, Vol. 77, No. 7. 1 January 2000 NMR in Biomedicine, Vol. 13, No. 3. Progressive Multifocal Leukoencephalopathy and Human Immunodeficiency Virus-associated White Matter Lesions in. Dec 01, 2003 · PURPOSE: To evaluate the effect of using the ferumoxides–poly-l-lysine PLL complex for magnetic cell labeling on the long-term viability, function, metabolism, and iron utilization of mammalian cells. MATERIALS AND METHODS: PLL was incubated with ferumoxides for 60 minutes, incompletely coating the superparamagnetic iron oxide SPIO through electrostatic interactions.
the incidence of idiopathic pulmonary fibrosis IPF may be as high as 30/100,000 in the U.S. population.IPF is a disease process characterized by alveolar epithelial cell injury and hyperplasia, inflammatory cell accumulation, fibroblast hyperplasia, deposition of extracellular matrix, and scar formation.The end result of this process is the loss of lung elasticity and loss of alveolar. Jul 02, 2012 · Significance: Sequestosome 1 p62/SQSTM1 is a multifunctional adapter protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis.Recent Advances: Recent evidence has revealed that p62/SQSTM1 has a critical role in an oxidative stress response pathway by its direct interaction with the ubiquitin ligase adaptor Kelch-like ECH-associated protein 1 KEAP1, which.
Jul 07, 2004 · Interferon IFN regulatory factors IRF are a family of transcription factors with multiple functions. IRF-7 was initially cloned within the biologic context of Epstein-Barr virus EBV latency and discovered to have an intimate relation with the EBV primary oncogenic protein, latent membrane protein-1 LMP-1. The growing number of advances in human genomic research that are directly relevant to disease diagnosis, treatment, and prevention coupled with the declining cost of genome sequencing has promoted the use of genomic technologies in routine clinical care.Among the many challenges to widespread implementation of genomic medicine, what looms largest is the lack of evidence to. Readers who wish to review core principles of genetics and genomics. contributes to disease pathogenesis, particularly in cancer 25 and diseases caused by. Human Genome Research. To provide stem cell emphasis and laboratory training to pre-doctoral, post-doctoral and clincal fellows at Stanford. This program has a focus on "translational medicine", which exists at the crossroads of stem cell biology, regenerative medicine and human disease. Program seeks. Biology, an international, peer-reviewed Open Access journal. Department of Internal Medicine, University of Nebraska Medical Center, Veteran Affairs Medical Center, 4101 Woolworth Ave, R151, Omaha, NE 68105-8080, USA.
A part of the research in the lab, employing genetically modified mouse models of human diseases, endothelial progenitor cells/stem cells, and translational research approach as well as nanomedicine, is to elucidate the molecular mechanisms of endothelial regeneration and resolution of inflammatory injury and determine how aging and epigenetics. Oral cancer is one of the major global threats to public health. Oral cancer development is a tobacco-related multistep and multifocal process involving field cancerization and carcinogenesis. The rationale for molecular-targeted prevention of oral cancer is promising. Biomarkers of genomic instability, including aneuploidy and allelic imbalance, are able to measure the cancer risk of oral. Mar 06, 2020 · Currently accepting applications for positions available starting July 1, 2020. The deadline to apply is March 15, 2020. The mission of the NIH-funded CT 2 program is to train the next generation of leaders in the field of oncology drug and diagnostic development. It is open to both PhDs and MDs and the training consists of 2 years of mentored research clinical or laboratory. PGC-1α and Adaptive Thermogenesis. PGC-1α was originally discovered as a cold-inducible transcription coactivator of adaptive thermogenesis, a physiological process through which energy is dissipated as heat in response to environmental conditions such as cold stress and overfeeding 8, 51.BAT and skeletal muscle are the two major organs involved in this process. Ultimately, we hope that our studies in these areas to lead to the development of novel therapeutics for the treatment of various types of human cancer. Current Appointments & Affiliations Donald and Elizabeth Cooke Distinguished Professor of Cancer Research, in the School of Medicine, Pharmacology & Cancer Biology, Basic Science Departments 2009.
Dean W. Felsher is part of Stanford Profiles, official site for faculty, postdocs, students and staff information Expertise, Bio, Research, Publications, and more. The site facilitates research and collaboration in academic endeavors. Innate immunity constitutes the first line of defence against both external and endogenous threats in the brain, and microglia cells are considered key mediators of this process. Recent studies have. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 HIV-1.
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