Leukocyte Depletion in Cardiac Surgery and Cardiology - kelloggchurch.org

Leukocyte depletion during cardiac operationa new.

Nov 01, 2001 · The concept of leukocyte depletion has been acknowledged as a mandatory procedure in transfusion medicine for a while. Within recent years, leukocyte removal filters have also become a more and more important tool in cardiac surgery, where this procedure is a logical strategy to limit neutrophil-mediated disorders. Leukocyte depletion in cardiac surgery and cardiology. Basel; New York: Karger, ©2002 OCoLC606051550 Online version: Leukocyte depletion in cardiac surgery and cardiology. Basel; New York: Karger, ©2002 OCoLC606676047: Document Type: Book: All Authors / Contributors: Georg Matheis; Anton Moritz; Martin Scholz. General Considerations: Leukocyte Biology and Pathogenicity in Cardiac Surgery and Cardiology - The Need for Leukocyte Depletion, T. Gourlay, G. Asimakopoulos, K.M. Taylor; Leukocyte-Mediated Cerebral Disorders during and after Cardiac Surgery, M. Scholz, G. Wimmer-Greinecker, G. Matheis; Mechanisms and Technical Aspects of Leukocyte Depletion. Leukocyte depletion recently has been introduced for cardiac surgical patients to attenuate leukocyte-mediated inflammation and organ reperfusion injury. We evaluated the feasibility of a new leukocyte depletion method in which systemic leukocyte depletion is achieved through the venous side of the cardiopulmonary bypass circuit under low blood flow.Methods. Thus, leukocyte depletion may be beneficial as an adjunct to terminal blood cardioplegia or blood cardioplegia during cardiac surgery to attenuate leukocyte-mediated ischemia-reperfusion injury in patients with compromised hearts, such as those with preoperative ischemic insults, severe left ventricular hypertrophy, and in pediatric patients.

Nov 30, 2008 · Cardiopulmonary bypass is associated with systemic inflammation that may contribute to increased perioperative mortality. Depletion of circulating leukocytes may reduce the inflammatory response. We studied the effect of a leukocyte depleting filter on leukocyte activation during cardiopulmonary bypass in high risk patients. Leukocyte-depleted blood cardioplegia was useful in pediatric patients. Thus, leukocyte depletion may be beneficial as an adjunct to terminal blood cardioplegia or blood cardioplegia during cardiac surgery to attenuate leukocyte-mediated ischemia-reperfusion injury in. Despite promise from earlier studies, however, the value of intraoperative leukocyte-depletion LD remains equivocal. We studied the effect of LD during routine cardiac surgery. Leukocyte depletion during cardiopulmonary bypass has been demonstrated in animal experiments to improve pulmonary function. Conflicting results have been reported, however, with clinical depletion by arterial line filter of leukocytes at the beginning of cardiopulmonary bypass. Activated leukocytes may increase morbidity in cardiac surgery. The objective of this study is to investigate the influence on morbidity of leukocyte-depleting blood filters placed into the.

Leukocyte depletion results in improved lung function and.

Myocardial Protection With Leukocyte Depletion in Cardiac.

Leukocyte depletion during CPB, although controversial, can reduce unwanted inflammatory response [8, 9], decreasing IL-6 and IL-8 activity, with possible improvement in hemodynamic parameters and the oxygenation index [9–11]. On the other hand, the effect of filtration on anti-inflammatory levels of interleukins such as IL-10 and IL-1rA is not very clear. Leukocyte filtration has evolved as an important technique in cardiac surgery with cardiopulmonary bypass to prevent pathogenic effector functions mediated by activated leukocytes. The underlying mechanisms that result in an improvement of laboratory variables as well as clinical outcome. Feb 01, 2011 · Objective: Cardiopulmonary bypass CPB elicts an inflammatory response which is potentially harmful and that is partly caused by activation of leukocytes. Despite promise from earlier studies, however, the value of intraoperative leukocyte-depletion LD remains equivocal. We studied the effect of LD during routine cardiac surgery. In the leukocyte-depletion group n = 20, all residual blood 1.2 to 2.1 L was filtered by leukocyte- removal filters and reinfused after cardiopulmonary bypass, whereas in the control group an identical amount of residual blood after cardiopulmonary. Cardiopulmonary bypass CPB which is widely used in cardiac surgery is associated with an inflammatory response. This inflammatory reaction contributes to an organ dysfunction which may sometimes lead to severe complications or even mortality. It is well-known that leukocytes play a major role in the production of this inflammatory process.

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